Introduction. Analyze comprehensive strategy for national technological sovereignty and the development of research centers with the participation of technical universities is the purpose of this study. The regulatory mechanisms, structural characteristics, and practical results of implementing the state strategy are examined. Particular attention is paid to the role of China's technical universities in the integrated model of science and education. The integration of technology, scientific research, and human resource development facilitates the formation of innovative scientific clusters, which serve not only as a market ecosystem but also as an element and mechanism for implementing the state's long-term development strategy. Methods and Materials. The study is based on a system approach that views objects as complex systems consisting of interconnected elements. This approach is relevant for studying universities and research organizations, allowing for consideration of their multi-level structure and interaction dynamics. The materials are presented in key strategic documents designed to stimulate the development of scientific and technological fields in China.  Results. State policy in China directs technical universities to play a crucial role in the national innovation system. They reproduce scientific knowledge, train highly skilled personnel, and transfer technology to the real economy. Unlike traditional models, where universities primarily focus on education, Chinese technical and engineering institutions are tasked with implementing state technological priorities. The development of innovation clusters in China is spatially differentiated. Discussion and Conclusion. In various regions of the country, scientific clusters have formed with clear industry specialization, determined by historical prerequisites, the availability of a scientific, educational and technological base, industrial infrastructure, a historically established university community and state policy priorities. The study findings may be of interest to specialists in applied research in international regional studies, as well as to those studying the development of government governance of universities and the scientific and technological sector.